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24-Hour Urine Lysozyme Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of lysozyme, a protein that helps fight bacteria, in your urine over a 24-hour period. It may be used to check for conditions affecting your immune system or kidney function.

Quick summary

["Lysozyme helps protect your body from infections; abnormal levels may signal immune or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75640-3
Short code
Lysozyme 24h Ur-sCnc
Synonyms
Lysozyme 24h Ur-sCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like frequent infections, kidney problems, or if you’re being evaluated for conditions such as chronic granulomatous disease or certain immune disorders. It can also help monitor kidney function or response to treatment.

What Does the Test Involve?

You’ll collect all urine produced in a 24-hour period in a special container. The sample is then sent to a lab for analysis. This requires careful timing and proper storage of the urine collection.

What to Expect Before the Test

No special preparation is needed, but you should drink enough fluids to produce urine throughout the day. Avoid certain medications or supplements that might interfere with the test results, as directed by your provider.

What to Expect During the Test

You’ll collect urine in a container for 24 hours, typically starting after you urinate in the morning. Empty your bladder at the start and end of the collection period, discarding those samples. Keep the container refrigerated if possible to prevent bacterial growth.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Lysozyme (24-hour)

Frequently asked questions

What does a lysozyme test result mean?
Elevated lysozyme levels in urine may indicate an overactive immune response, such as in chronic granulomatous disease or certain inflammatory conditions. Low levels could suggest immune deficiencies or kidney issues that affect protein filtration. Results should always be interpreted by a healthcare provider in the context of your overall health and symptoms.
How often is this test recommended?
This test is typically ordered as needed, depending on your symptoms or medical condition. Your healthcare provider will determine if repeat testing is necessary based on your results and ongoing care.
Can lysozyme levels change with diet or medications?
Dietary changes or certain medications may not significantly affect lysozyme levels in urine. However, always inform your healthcare provider about all medications, supplements, or recent changes in diet to ensure accurate test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy