Lysozyme/Creatinine Ratio, Urine
A urine test that measures lysozyme relative to creatinine, helping assess kidney tubular injury and monitor certain conditions.
["This ratio can help identify and monitor kidney tubular damage, especially when an elevated urine lysozyme level alone may be affected by urine concentration."]
Key facts at a glance
- LOINC
- 34336-8
- Short code
- Lysozyme/Creat Ur-Rto
- Synonyms
- Lysozyme/Creat Ur-Rto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amount of lysozyme, an enzyme produced by white blood cells, in urine and compares it with the amount of creatinine in the same sample. Creatinine is used as a reference because its level in urine varies with urine concentration.
Why might I need this test?
The test may be used to evaluate or monitor conditions that can injure the kidney tubules, which reabsorb water and nutrients from filtered blood. Your clinician may also order it when monitoring certain blood, immune, or digestive disorders associated with increased lysozyme.
How is the test performed?
You provide a urine sample. The laboratory measures lysozyme and creatinine in the sample and calculates their ratio. The results are interpreted with your symptoms, medical history, and other kidney tests.
How do I prepare for the test?
Follow your clinician's instructions about when and how to collect the urine. If a random specimen is requested, a clean-catch midstream urine sample is usually preferred. Fasting is generally not required, but follow any instructions provided by your care team.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A higher-than-expected ratio may indicate increased urinary loss of lysozyme, which can occur with kidney tubular injury or reduced kidney filtration. Increased lysozyme production related to certain blood or immune disorders may also raise the result. The ratio should be interpreted by your clinician because urine concentration, kidney function, and other factors can affect it.
Short name
Urine Lysozyme/Creatinine Ratio
Frequently asked questions
Is this the same as a standard urine protein test?
Does an abnormal result mean I have kidney disease?
Will I need to collect urine for a specific period?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy