Skip to content

Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulins. Proteins are essential for many bodily functions, including transporting nutrients and maintaining fluid balance.

Quick summary

["Total protein levels help assess your body’s protein status and potential health risks like dehydration or liver/kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100654-3
Short code
M2-PK Stl Ql
Synonyms
M2-PK Stl Ql
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. It can also help diagnose dehydration or monitor chronic conditions like kidney disease or inflammatory disorders.

What to Expect

A small blood sample is taken from your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The sample is sent to a lab for analysis.

Normal vs. Abnormal Results

While reference ranges can vary by lab, higher levels might suggest dehydration or conditions like multiple myeloma, while lower levels could indicate liver disease, malnutrition, or kidney problems. Your provider will interpret results in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor liver function, kidney health, and nutritional status. It can also help detect protein-losing conditions, such as gastrointestinal disorders or immune system issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

How long does it take to get my results?
Results are typically available within 1 to 3 business days, depending on your lab. Your provider will contact you once they’re ready for review.
Can I eat or drink before this test?
No special preparation is needed. However, if you have a history of clotting issues, let your provider know before the test.
What if my protein levels are too high or too low?
If your results are outside the expected range, your provider will discuss possible causes, such as medical conditions or lifestyle factors, and recommend next steps for treatment or further testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy