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Anti-Mannose-Binding Lectin (MBL) Serum Concentration (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of mannose-binding lectin (MBL) in your blood serum. MBL is a protein produced by your liver that helps your immune system fight off infections.

Quick summary

["MBL helps identify immune system function and potential susceptibility to certain infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77735-9
Short code
M absces erm(41) trunc Islt/Spm Ql
Synonyms
M absces erm(41) trunc Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Mannose-Binding Lectin (MBL)?

MBL is a protein in your blood that acts as part of your natural immune defense. It binds to sugars on the surface of some bacteria and viruses, marking them for destruction by white blood cells. Your body produces MBL in the liver, and its levels can vary widely among individuals.

Why Might You Need This Test?

Doctors may order this test if you have a history of recurrent infections, especially those caused by certain bacteria or viruses, or if you have conditions like chronic sinusitis, pneumonia, or severe diarrhea that suggest an impaired immune response. It may also be used in research or genetic testing for immune-related disorders.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then processed to separate the serum (the liquid part after clotting). The MBL protein is measured using a specialized immunoassay technique to determine its concentration.

What Do the Results Mean?

Results are reported as a quantitative measurement of MBL in your serum. While reference ranges can vary by lab, very low levels may indicate a genetic predisposition to certain infections, while higher-than-normal levels might be seen in certain inflammatory conditions or after liver disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: MBL and Immune Function

Short name

MBL Serum Level

Frequently asked questions

What causes low MBL levels?
Low levels of MBL can sometimes be due to genetic mutations that affect its production. These mutations may increase your risk of infections caused by certain bacteria or viruses, particularly those that trigger the complement system through the lectin pathway.
What if my MBL level is high?
High MBL levels may be associated with certain inflammatory conditions or liver diseases, but they can also occur naturally without clinical significance. Your doctor will consider your overall health and symptoms when interpreting results.
Can MBL levels change over time?
Yes, MBL levels can fluctuate due to infections, inflammation, or liver function. If your doctor orders this test repeatedly, they may monitor changes to assess your immune response or underlying conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy