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Serum Amylase Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of amylase, an enzyme produced mainly by the pancreas and salivary glands, in your blood serum. Amylase helps break down carbohydrates.

Quick summary

["Amylase levels help diagnose conditions affecting digestion or pancreas health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2591-6
Short code
Macroamylase SerPl-cCnc
Synonyms
Macroamylase SerPl-cCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to investigate symptoms like persistent abdominal pain, nausea, vomiting, or unexplained weight loss. It can also help identify conditions such as pancreatitis, pancreatic cancer, or other digestive issues. Sometimes, elevated amylase levels may signal an infection or injury to the pancreas or salivary glands.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. The process is quick and usually painless. If you’re on blood thinners or have a history of bleeding disorders, let your doctor know beforehand.

What Happens During the Test?

Blood is collected from a vein in your arm using a needle. The sample is then sent to a lab for analysis. The test typically takes a few minutes to complete, and the results are usually available within 24 to 48 hours.

Possible Results and Interpretation

Amylase levels can vary based on factors like diet, medications, or underlying health conditions. High levels may indicate acute pancreatitis, pancreatic cysts, or other digestive issues. Low levels are less common but could suggest pancreatic insufficiency or certain metabolic disorders. Your doctor will discuss the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Amylase

Frequently asked questions

What Are Common Causes of Elevated Amylase Levels?
Elevated serum amylase levels are often linked to conditions affecting the pancreas, such as pancreatitis (inflammation), pancreatic tumors, or blockages. Other causes include infections, kidney disease, or certain medications. Salivary gland disorders, like sialadenitis (inflammation), can also raise amylase levels.
What Are Common Causes of Low Amylase Levels?
Low serum amylase levels are less common but may occur in cases of chronic pancreatitis, pancreatic insufficiency, or certain genetic disorders. Rarely, it can be due to malnutrition or liver disease. Your doctor will evaluate the results alongside other tests and symptoms to determine the cause.
Can Amylase Levels Change with Diet or Medications?
Yes, diet and medications can influence amylase levels. Eating high-carbohydrate foods shortly before the test may temporarily increase amylase. Some medications, like certain diuretics or antibiotics, might also affect enzyme levels. Always inform your doctor about any medications you’re taking.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy