Skip to content

Cerebrospinal Fluid (CSF) Macrophage Count

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of macrophages (a type of white blood cell) found in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord.

Quick summary

["Macrophages in CSF can help diagnose or monitor conditions affecting your nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12229-1
Short code
Macrophages NFr CSF Manual
Synonyms
Macrophages NFr CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is a CSF Macrophage Count Used For?

CSF macrophage counts are often used to evaluate conditions that involve inflammation, infection, or immune responses in the central nervous system (CNS). They may be part of a broader evaluation for conditions like meningitis, multiple sclerosis, or certain types of brain tumors.

When Might You Need This Test?

Your healthcare provider may order this test if you have symptoms such as headaches, neck stiffness, confusion, seizures, or neurological symptoms that suggest an issue with your brain or spinal cord. It may also be used in research or specialized diagnostic scenarios.

How Is the Test Performed?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then examined under a microscope to count macrophages and other cells.

What Are Possible Results?

Results are typically reported as the absolute number of macrophages per microliter (µL) of CSF. Higher than expected counts may indicate inflammation, infection, or other immune-related processes in the CNS.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated macrophage counts in CSF can signal conditions such as chronic meningitis, certain types of encephalitis, or demyelinating diseases like multiple sclerosis. Lower counts may be normal or could indicate conditions affecting macrophage function or migration. Always discuss results with your healthcare provider for accurate interpretation.

Short name

CSF Macrophage Count

Frequently asked questions

Why might my CSF macrophage count be checked?
Your healthcare provider may check this count to investigate symptoms like unexplained headaches, neurological deficits, or signs of inflammation in your brain or spinal cord. It can help determine whether an immune response or infection is present.
What do abnormal results mean?
Abnormal results (higher or lower than expected macrophage counts) may suggest conditions like chronic inflammation, infection, or autoimmune diseases affecting the central nervous system. Your provider will discuss these findings with you and may recommend further testing or treatment.
Can lifestyle changes affect this test?
Generally, lifestyle factors like diet or exercise do not directly affect CSF macrophage counts. However, conditions like infections, autoimmune diseases, or recent trauma to the head or spine may influence results. Always follow your provider’s guidance for test preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy