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Macrophage Count in Blood (Qualitative or Semi-Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates the number or presence of macrophages in your blood, which are immune cells that help fight infections and remove waste. It may be used to assess immune function or diagnose conditions affecting these cells.

Quick summary

["Macrophages are key defenders in your immune system; this test helps check their role in health or disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68412-6
Short code
Macrophages NFr Vitf Manual
Synonyms
Macrophages NFr Vitf Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent infections, unexplained fatigue, or signs of an immune disorder. It could also be part of a broader evaluation for conditions like chronic inflammation, certain cancers, or autoimmune diseases.

What to Expect Before the Test

No special preparation is usually needed. You may have a simple blood draw, similar to other routine tests. If you’re on blood thinners or have a history of bleeding disorders, let your provider know before the test.

What the Results Mean

Results are qualitative (present/absent) or semi-quantitative (approximate levels), meaning they describe whether macrophages are detected or their relative abundance rather than exact numbers. Abnormal findings may prompt further testing or evaluation of your symptoms.

Common Conditions Linked to Macrophage Testing

High or abnormal macrophage counts might suggest chronic infections, certain cancers (like leukemia), or immune system overactivity. Low or absent counts could indicate immune deficiencies or rare genetic disorders affecting white blood cell function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Macrophage Presence/Level Check

Frequently asked questions

What does a positive or negative result mean?
A positive result indicates the presence of macrophages in your blood, which is normal for healthy immune function. A negative or altered result may warrant additional testing to explore underlying causes, such as immune disorders or genetic conditions.
How often should I get this test?
The frequency depends on your symptoms, medical history, and provider’s recommendations. Some patients may need this test periodically if they have chronic conditions affecting macrophages, while others may only need it once for diagnostic purposes.
Can lifestyle changes affect macrophage counts?
While lifestyle factors like diet, exercise, and stress can influence immune function broadly, this specific test does not measure absolute macrophage numbers. However, maintaining a healthy lifestyle may support overall immune health, which indirectly supports macrophage activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy