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Major Protein Transferrin Level (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of transferrin, a protein in your blood that helps carry iron to your body’s tissues.

Quick summary

["Transferrin helps maintain healthy iron levels and supports red blood cell production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46275-4
Short code
Maj XM p transf rx SerPl-Imp
Synonyms
Maj XM p transf rx SerPl-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Transferrin?

Transferrin is a blood protein that binds iron and transports it throughout your body. It plays a key role in preventing iron buildup and ensuring iron is available where it’s needed, such as in red blood cells. Low levels may indicate conditions affecting iron metabolism or liver function.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like fatigue, pale skin, or signs of iron deficiency. It can also help evaluate liver disease, kidney problems, or certain genetic disorders that affect protein function.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis, where transferrin levels are measured using an immunoassay method to detect its presence.

What Are Possible Results?

Results are reported as a concentration of transferrin in the blood, though exact reference ranges vary by lab. Abnormal results may signal conditions like iron deficiency anemia, liver disease, or other metabolic disorders.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Transferrin Level

Frequently asked questions

How often will I need this test?
This test is often ordered as part of a broader evaluation for iron metabolism, liver function, or anemia. Your doctor will determine frequency based on your symptoms, medical history, or ongoing health needs.
What do low or high transferrin levels mean?
Low transferrin levels may suggest iron deficiency, liver disease, or chronic inflammation. High levels could indicate conditions like malnutrition, severe liver disease, or certain genetic disorders. Always discuss results with your healthcare provider.
Can diet affect transferrin levels?
Yes, diet can influence transferrin. High iron intake or certain dietary deficiencies (like protein or vitamin C) may impact levels. Your doctor may recommend dietary adjustments or supplements if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy