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Alpha-1 Antitrypsin (A1AT) Serum Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced mainly in the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung and liver damage; low levels may indicate genetic disorders or chronic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81825-2
Short code
MAN2B1 Mut Anl Bld/T
Synonyms
MAN2B1 Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to diagnose or monitor conditions like Alpha-1 Antitrypsin deficiency, which can lead to lung diseases (such as chronic obstructive pulmonary disease) or liver problems. It may also be used to check for liver inflammation or damage.

What to Expect Before the Test

No special preparation is needed. You may drink water but avoid eating for a few hours before the blood draw. Wear a loose shirt if you need to roll up your sleeve for the test.

What Happens During the Test

A healthcare professional will insert a small needle into a vein in your arm to collect a blood sample. You may feel a brief pinch, but it usually doesn’t cause significant discomfort. The blood is then sent to a lab for analysis.

What the Results Mean

Results are compared to a reference range, which can vary by lab. Low levels of Alpha-1 Antitrypsin may suggest genetic mutations or conditions affecting protein production. High levels might be due to liver disease or other factors.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin

Frequently asked questions

What causes low Alpha-1 Antitrypsin levels?
Low Alpha-1 Antitrypsin levels are often due to genetic mutations passed down through families. However, other conditions like liver disease, chronic inflammation, or certain medications may also temporarily lower the protein levels.
How is Alpha-1 Antitrypsin deficiency diagnosed?
Diagnosis typically involves blood tests to measure Alpha-1 Antitrypsin levels, genetic testing to identify mutations, and sometimes imaging or lung function tests to assess complications like lung damage or cirrhosis.
Can lifestyle changes help manage Alpha-1 Antitrypsin deficiency?
Yes, lifestyle modifications such as quitting smoking, avoiding lung irritants, maintaining a healthy weight, and following a balanced diet can help reduce symptoms and slow disease progression. Some patients may also receive enzyme replacement therapy or other treatments prescribed by their doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy