24-Hour Urine Manganese Excretion Rate
This test measures how much manganese your body excretes in urine over a 24-hour period. Manganese is a mineral that plays a role in metabolism and nerve function, but high levels can indicate potential health concerns.
["Assessing manganese loss in urine helps identify possible manganese toxicity or metabolic disorders."]
Key facts at a glance
- LOINC
- 42222-0
- Short code
- Manganese 24h Ur-sRate
- Synonyms
- Manganese 24h Ur-sRate
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like joint pain, nerve damage, or signs of manganese buildup in the body. It may also be used in research or monitoring for individuals exposed to high manganese levels (e.g., occupational hazards).
What to Expect Before the Test
No special preparation is needed. Collect all urine produced in a 24-hour period (typically from midnight to midnight) in a clean container. Drink plenty of fluids to ensure full collection.
How the Test Is Performed
The collected urine sample is sent to a lab for analysis. Manganese levels are measured using a specialized technique, often involving mass spectrometry or atomic absorption spectroscopy.
Possible Results and Interpretation
Results are compared to reference ranges specific to your age, sex, and health status. Elevated levels may suggest manganese toxicity, kidney issues, or certain genetic conditions. Low levels may indicate malabsorption or other metabolic disorders.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High manganese excretion can signal manganese poisoning, which may affect the nervous system, liver, or kidneys. Chronic exposure or excess intake can lead to long-term health risks. This test helps monitor manganese metabolism and guide treatment decisions.
Short name
Manganese Urine Rate
Frequently asked questions
What causes abnormal manganese levels in urine?
Can diet affect this test result?
Is this test painful or uncomfortable?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy