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Manganese/Creatinine, Urine — Mass Ratio with Turbidimetric Creatinine Measurement

Published: August 9, 2026Updated: August 16, 2026

Measures manganese relative to urine creatinine. The ratio may help account for differences in urine concentration when evaluating manganese exposure.

Quick summary

["This test can help assess recent manganese exposure while adjusting for how concentrated the urine sample is."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110375-3
Short code
Manganese/Creat Msmt Ur
Synonyms
Manganese/Creat Msmt Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures manganese in urine and compares it with urine creatinine. Creatinine is commonly measured by turbidimetry, while manganese requires a trace-element laboratory method.

Why might I need this test?

A urine manganese test may be ordered to assess exposure to manganese from an occupational or environmental source. Results may be considered with exposure history, symptoms, blood tests, and other clinical findings.

How is the test performed?

A urine sample is collected and analyzed in a laboratory. The result may include the urine manganese concentration, the urine creatinine concentration, or a calculated manganese-to-creatinine ratio.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory or clinician, including whether a timed or spot collection is required. Stay well hydrated unless you have been given other instructions, and tell the care team about recent occupational or environmental manganese exposure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated urine manganese result may suggest recent increased exposure, but it must be interpreted using collection timing, workplace or environmental exposure history, and other clinical information. Urinary manganese can vary naturally, and the creatinine-adjusted ratio is intended to reduce the effect of differences in urine concentration.

Short name

Urine manganese/creatinine ratio

Frequently asked questions

Does this test diagnose manganese poisoning?
No. It can help assess exposure, but poisoning is diagnosed or excluded using exposure history, symptoms, physical examination, and supporting laboratory tests.
Why is creatinine included?
Urine concentration can vary with hydration and fluid intake. Comparing manganese with creatinine helps account for differences in how concentrated the urine sample is.
Do I need to fast before this test?
Fasting is generally not required for a routine urine manganese test. However, workplace testing programs may specify collection times and other safety precautions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy