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Manganese, Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of manganese, a trace mineral, in your blood serum. Manganese is important for bone formation, metabolism, and other bodily functions, but high levels can indicate potential health concerns.

Quick summary

["Your manganese level helps doctors assess exposure risks or underlying conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104858-6
Short code
Manganese IgE Qn
Synonyms
Manganese IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like fatigue, neurological issues, or signs of metal poisoning. They might also check it if you work in industries with manganese exposure (e.g., mining, manufacturing) or have certain genetic conditions.

What Does a Result Mean?

Results can vary based on your health, diet, and exposure. High levels may suggest manganese toxicity, while low levels could indicate deficiencies or metabolic issues. Your doctor will interpret results in the context of your overall health.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The serum portion is separated and sent to a lab for analysis. Avoid alcohol or certain medications before testing if instructed.

Common Causes of Abnormal Results

High manganese levels may result from occupational exposure, certain medications, or genetic disorders. Low levels could stem from malnutrition, liver disease, or metabolic disorders. Lifestyle factors like diet also play a role.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Chronic manganese exposure can damage the nervous system, kidneys, or liver. High levels may mimic Parkinson’s-like symptoms, while low levels might affect metabolism or bone health. Your doctor will guide further action based on your results and symptoms.

Short name

Manganese Level

Frequently asked questions

What triggers this test?
This test is often ordered if you have symptoms like neurological issues, metal poisoning concerns, or if your doctor suspects manganese-related health problems. It may also be part of routine monitoring for those with known exposure risks.
How is the test performed?
A simple blood draw is used to collect serum. The lab then analyzes the manganese concentration using specialized techniques like high-performance liquid chromatography (HPLC). No special preparation is usually needed beyond standard fasting guidelines if required.
Can diet affect manganese levels?
Yes, diet can influence manganese levels. Foods like nuts, whole grains, and tea contain manganese, while excessive intake of certain supplements or processed foods may alter results. Your doctor may recommend dietary adjustments if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy