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Manganese in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of manganese, a trace mineral, in your blood serum. Manganese is important for bone formation, metabolism, and nerve function, but high levels can indicate potential health concerns.

Quick summary

["Understanding your manganese levels helps assess exposure risks or metabolic needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
50875-4
Short code
Manganese RBC-sCnc
Synonyms
Manganese RBC-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like joint pain, neurological issues, or signs of heavy metal exposure (e.g., from occupational hazards). It may also be part of routine monitoring for certain conditions or after exposure to manganese-containing substances.

What Does the Result Mean?

Results are not standardized across labs, so your doctor will interpret them in the context of your health history and symptoms. High levels may suggest exposure to manganese, while low levels might indicate nutritional deficiencies or metabolic issues.

Common Causes of Abnormal Results

Elevated manganese levels can result from occupational exposure (e.g., mining, welding), certain medications, or liver/kidney dysfunction. Low levels may occur with poor diet, malabsorption, or metabolic disorders.

What Should You Do Next?

Follow your doctor’s advice based on the test results. If exposure is suspected, they may recommend lifestyle changes, dietary adjustments, or further testing to identify underlying causes.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Manganese is essential for normal bodily functions, but chronic exposure or imbalances can affect nerve function, bone health, and metabolism. High levels may require medical evaluation to address exposure or organ function.

Short name

Manganese Level

Frequently asked questions

What triggers this test?
Symptoms like joint pain, numbness, or neurological issues, occupational history with manganese exposure, or as part of routine monitoring for conditions like Wilson’s disease or metabolic disorders.
How is this test performed?
A blood sample is drawn from a vein, typically in your arm. The serum portion is then analyzed in a lab to measure manganese concentration using a specialized method (often nephelometry or immunoassay).
Can I prepare for this test?
No special preparation is needed, but avoid heavy exercise or eating a large meal before the draw to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy