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Milk protein (casein) concentration, 24-hour urine

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of casein protein found in your urine over a 24-hour period. Casein is a major protein in milk and can appear in urine if there is kidney damage or abnormal protein loss.

Quick summary

["This test helps assess kidney function by detecting excessive protein loss in urine, which may indicate kidney disease or other conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
112225-8
Short code
Mare milk IgE Qn IA
Synonyms
Mare milk IgE Qn IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like swelling, frequent urination, or unexplained weight changes. It may also be used to monitor kidney health in people with conditions like diabetes, high blood pressure, or a history of kidney problems.

What to Expect Before the Test

You’ll need to collect all your urine for 24 hours, typically starting and ending with your first morning urine. Store the samples in a refrigerator or freezer to keep them fresh. Follow your provider’s instructions carefully to ensure accurate results.

How the Test Works

The collected urine is analyzed to measure the total casein protein content. This helps determine if your kidneys are retaining protein normally or if protein is leaking into your urine.

Possible Results and Interpretation

Higher-than-normal casein levels in urine may suggest kidney problems, such as nephrotic syndrome or kidney disease. Your provider will discuss the results with you and may recommend further testing or treatment if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Casein Test

Frequently asked questions

What causes elevated casein in urine?
Elevated casein in urine can be caused by kidney diseases (e.g., glomerulonephritis, nephrotic syndrome), heavy exercise, or certain medications. It may also appear in people with conditions like multiple myeloma or severe dehydration.
How often should this test be repeated?
Your provider may repeat this test if initial results are abnormal or if you have ongoing kidney concerns. Follow their guidance on follow-up testing based on your specific situation.
Can diet affect this test?
Yes, high-protein diets (like those in some medical conditions) or excessive milk intake may temporarily increase casein in urine. Avoid large amounts of milk or high-protein foods for a few days before testing if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy