Skip to content

Methylmalonic Acid in Serum or Plasma (MMA)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of methylmalonic acid, a breakdown product of certain amino acids, in your blood. It helps diagnose and monitor conditions affecting how your body processes these nutrients.

Quick summary

["MMA levels can signal vitamin deficiencies or metabolic disorders that require medical attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14237-2
Short code
MBP IgA Ser-aCnc
Synonyms
MBP IgA Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, muscle weakness, or neurological issues that could be linked to vitamin deficiencies (such as B12 or folate) or metabolic disorders. It’s also used to check for inherited conditions like methylmalonic aciduria.

Common Conditions Monitored

This test is particularly useful for tracking conditions like pernicious anemia (due to B12 deficiency), certain inherited metabolic disorders, or chronic kidney disease, where MMA levels may rise.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis using a specialized method to measure MMA concentration.

What to Expect Before the Test

No special preparation is needed, but avoid strenuous activity or eating heavy meals 24 hours before the test if instructed by your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Level

Frequently asked questions

What causes MMA levels to be abnormally high?
Abnormally high MMA levels can result from vitamin deficiencies (like B12 or folate), inherited metabolic disorders (such as methylmalonic aciduria), chronic kidney disease, or certain medications that interfere with metabolism.
What does a normal MMA level mean?
A normal MMA level suggests your body is processing nutrients efficiently, though it doesn’t rule out all underlying causes. Your doctor may recommend further testing if symptoms persist.
Can diet affect MMA test results?
Diet alone typically doesn’t affect MMA test results, but certain foods or supplements (like high-protein diets or specific vitamins) may influence related metabolic processes. Follow your doctor’s guidance on fasting or dietary restrictions if applicable.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy