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C-reactive protein (CRP) with high-sensitivity measurement (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess low-level inflammation that may not be detected by other tests.

Quick summary

["High-sensitivity CRP helps track subtle inflammation, often used alongside other tests to monitor conditions like heart disease risk or autoimmune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111285-3
Short code
M cap caprip Ab Msmt Ser
Synonyms
M cap caprip Ab Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a high-sensitivity CRP test to evaluate your risk for heart disease, monitor chronic inflammatory conditions, or check for signs of infection or inflammation that aren’t easily detected with standard tests. It’s sometimes used in combination with other tests to guide treatment decisions.

How Is the Sample Collected?

A small amount of blood is drawn from a vein, usually in your arm. The blood is placed in a tube and sent to a lab for analysis. You may feel a brief pinch, but it’s typically over quickly. No special preparation is needed.

What Does the Test Measure?

High-sensitivity CRP measures very small amounts of CRP in your blood. CRP is a marker of inflammation, meaning it rises when your body responds to injury, infection, or other stressors. This test is particularly sensitive and can detect low levels of inflammation that might not be picked up by standard CRP tests.

What Might Affect Results?

Several factors can influence CRP levels, including recent illness, infection, injury, stress, certain medications (like steroids), or chronic conditions like arthritis or heart disease. Smoking, obesity, or poor diet may also affect results. It’s important to discuss your medical history and any recent activities with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

High-Sensitivity CRP (hs-CRP)

Frequently asked questions

How can this test help my healthcare provider?
This test helps your healthcare provider assess your risk for cardiovascular diseases, monitor chronic inflammatory conditions, or evaluate the effectiveness of treatments for conditions like rheumatoid arthritis or other autoimmune diseases. It may also be used to guide decisions about preventive care or treatment adjustments.
What does a high or low CRP level mean?
While CRP levels alone don’t diagnose a specific condition, consistently high levels may indicate ongoing inflammation or increased risk for heart disease. Consistently low levels might suggest reduced inflammation, but they don’t rule out other health concerns. Your results will be interpreted in the context of your overall health and medical history.
Do I need to prepare for this test?
No special preparation is needed for this test. You may be asked to fast before your blood draw if you’re having other tests that require fasting, but this is not required for CRP testing alone. Your healthcare provider will give you specific instructions if needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy