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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to assess low-level inflammation or risk for conditions like heart disease.

Quick summary

["hs-CRP helps track subtle signs of inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23260-3
Short code
M cap caprip Ab Ser Ql Aggl
Synonyms
M cap caprip Ab Ser Ql Aggl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP?

High-sensitivity C-reactive protein (hs-CRP) is a blood test that detects small amounts of CRP, a protein produced by the liver in response to inflammation. It’s particularly useful for identifying low-grade inflammation that could contribute to chronic diseases like cardiovascular disease.

Why Might You Need This Test?

Your doctor may order hs-CRP if you have risk factors for heart disease, such as high cholesterol, diabetes, or a family history of heart problems. It can also help monitor conditions like rheumatoid arthritis or other inflammatory diseases.

How Is the Test Done?

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis. Results are typically available within a few days.

What Do Results Mean?

Results are not given in absolute numbers but are compared to general reference ranges for healthy adults. Higher levels may indicate increased inflammation, while lower levels suggest reduced risk.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP plays a key role in assessing cardiovascular risk. Elevated levels may signal inflammation that could contribute to plaque buildup in arteries, increasing heart disease risk. It’s often used alongside other tests to guide treatment decisions.

Short name

hs-CRP

Frequently asked questions

What causes hs-CRP levels to change?
Several factors can influence hs-CRP levels, including infections, injuries, certain medications (like steroids), and underlying health conditions like arthritis or heart disease. Lifestyle factors like diet, exercise, and smoking also play a role.
How often should I get this test?
Your doctor will determine how often you need hs-CRP testing based on your medical history, risk factors, and overall health. It’s not a routine screening test but may be recommended periodically for certain conditions or risk assessments.
Can lifestyle changes affect hs-CRP levels?
Yes! Adopting a heart-healthy diet, staying physically active, managing stress, and avoiding smoking can help lower inflammation and potentially reduce hs-CRP levels over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy