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C-reactive protein, serum/plasma concentration (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation or infection.

Quick summary

["hsCRP helps track inflammation, often used alongside other tests to assess risk for heart disease or other conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23268-6
Short code
M cap caprip Ag Spec Ql IF
Synonyms
M cap caprip Ag Spec Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor chronic conditions like heart disease, rheumatoid arthritis, or other inflammatory disorders. It can also help evaluate risk for future health issues, such as heart attacks or strokes, especially in people with no obvious symptoms of inflammation.

What Does a High or Low Result Mean?

A higher-than-normal hsCRP level may indicate increased inflammation in your body. A lower level suggests less inflammation. However, results alone don’t diagnose a condition—they’re often used alongside other tests and clinical findings.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The blood is sent to a lab where it’s analyzed using a sensitive immunoassay method to measure the protein concentration.

What Should You Expect Before or After the Test?

There are no special preparations needed. You may feel slight discomfort from the needle, but it usually goes away quickly. If you’re on blood thinners, let your provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hsCRP

Frequently asked questions

What does a high hsCRP level mean for my health?
A high hsCRP level may indicate increased inflammation in your body, which could be linked to higher cardiovascular risk. Your provider will consider this along with other factors, such as your medical history and lifestyle, to determine next steps.
Can lifestyle changes affect hsCRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation. Making positive changes—such as eating a heart-healthy diet, staying active, and avoiding smoking—may help lower hsCRP levels over time.
How often should I get this test?
Your provider will decide how often to check your hsCRP based on your health needs. Some people get it yearly, while others may need it more or less frequently depending on their condition and treatment plan.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy