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Nucleic Acid Detection in Serum/Plasma by Probe-Based Assay

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material (DNA or RNA) in your blood using a specialized probe. It may be used to detect infections, genetic conditions, or other abnormalities.

Quick summary

["This test helps identify if certain viruses, bacteria, or genetic material are present in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105666-2
Short code
M catarhls DNA Spec Ql NAA+probe
Synonyms
M catarhls DNA Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific sequences of nucleic acids (DNA or RNA) using a molecular probe. If your blood contains the target genetic material, the probe will bind to it, confirming a positive result. This method is highly sensitive and can detect very small amounts of genetic material.

How the Test Works

Your blood sample is processed to extract nucleic acids. A probe—small, labeled molecules designed to match a specific genetic sequence—binds to these acids if they are present. Detection methods (such as fluorescence or color change) confirm the presence of the target nucleic acid.

Common Uses

This test may be used for diagnosing infections (e.g., viral infections like COVID-19), detecting genetic disorders, or monitoring conditions where nucleic acids are relevant (e.g., cancer research or research studies).

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast or avoid certain medications if directed by your healthcare provider. Bring any relevant medical records or questions about your test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Nucleic Acid Test (Qualitative)

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test to confirm or rule out infections, genetic conditions, or other conditions where nucleic acids are relevant. It can also be part of research studies or diagnostic screening for conditions like hereditary diseases or viral infections.
What does a positive result mean?
A positive result indicates the presence of the target nucleic acid sequence in your blood, which may suggest an infection, genetic condition, or other underlying issue. Your doctor will discuss the next steps based on your clinical context.
What does a negative result mean?
A negative result means the specific nucleic acid sequence was not detected in your sample. However, this does not always rule out the condition—other tests or follow-up may be needed to confirm your health status.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy