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Mean Corpuscular Hemoglobin Concentration (MCHC) from Red Blood Cells (RBCs) via automated hematology analysis

Published: August 9, 2026Updated: August 17, 2026

This test measures the average concentration of hemoglobin (the oxygen-carrying protein in red blood cells) within individual RBCs. It helps assess whether your RBCs are carrying enough oxygen.

Quick summary

["MCHC helps diagnose conditions like anemia or iron deficiency by checking if your RBCs are properly packed with hemoglobin."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
786-4
Short code
MCHC RBC Auto-EntMCnc
Synonyms
MCHC RBC Auto-EntMCnc
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is MCHC Used For?

Doctors use MCHC to diagnose and monitor certain types of anemia, such as iron deficiency anemia or sickle cell disease. It can also help identify conditions affecting red blood cell production or structure.

How Is This Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The sample is then analyzed automatically in a lab to measure the hemoglobin concentration inside each RBC.

What Does a Low or High MCHC Mean?

Low MCHC may suggest iron deficiency, hemolytic anemia, or other blood disorders where RBCs don’t contain enough hemoglobin. High MCHC can indicate conditions like hereditary spherocytosis or severe dehydration, where RBCs are packed with too much hemoglobin.

Common Conditions Linked to MCHC Results

Changes in MCHC are often part of a broader evaluation for anemia, blood disorders, or systemic diseases affecting red blood cells. It’s rarely the sole test but helps guide further testing if needed.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MCHC (RBC)

Frequently asked questions

Why might my doctor order an MCHC test?
Your doctor may order this test if you have symptoms like fatigue, pale skin, or shortness of breath, or if they suspect anemia, blood disorders, or other conditions affecting RBCs. It’s also part of routine blood work in some cases.
How long does it take to get results?
Results are typically available within 1–2 business days, depending on your lab’s processing time. Follow-up with your doctor to discuss any changes in your results.
Can I prepare for this test?
No special preparation is needed. However, avoid heavy meals or strenuous activity right before the blood draw to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy