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Serum or plasma mass concentration of ceruloplasmin (total copper-binding protein)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of ceruloplasmin, a protein in your blood that helps transport copper and protects against oxidative damage.

Quick summary

["Ceruloplasmin helps identify copper metabolism issues, such as Wilson’s disease or liver disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
28540-3
Short code
MCHC RBC-EntMCnc
Synonyms
MCHC RBC-EntMCnc
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Ceruloplasmin?

Ceruloplasmin is a copper-containing enzyme produced mainly by the liver. It plays a key role in copper metabolism and acts as an antioxidant by neutralizing free radicals in your blood. Low levels may suggest conditions like Wilson’s disease, liver disease, or certain infections.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like fatigue, abdominal pain, or neurological issues that could relate to copper imbalance. It’s also used to monitor treatment for conditions affecting copper metabolism.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a different method. Bring any medications you’re taking to your appointment.

What Happens During the Test?

A healthcare provider will collect a blood sample from a vein in your arm. The sample is sent to a lab for analysis using a specialized technique to measure ceruloplasmin concentration.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Ceruloplasmin level

Frequently asked questions

What causes ceruloplasmin levels to be abnormal?
Abnormal ceruloplasmin levels can result from conditions like liver disease, Wilson’s disease, infections, or certain medications. Your doctor will review your symptoms and other test results to determine the cause.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once they’re ready to discuss the findings.
Can diet affect ceruloplasmin levels?
Dietary copper intake may indirectly influence ceruloplasmin levels, but direct dietary changes aren’t typically recommended unless advised by your doctor. Focus on maintaining a balanced diet and following your healthcare provider’s guidance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy