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Mean Corpuscular Hemoglobin Concentration (MCHC) from Red Blood Cells

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of hemoglobin inside your red blood cells, expressed as its concentration. Hemoglobin is the protein that carries oxygen in your blood.

Quick summary

["Your doctor may check this test to assess red blood cell health or detect conditions affecting hemoglobin production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
59467-1
Short code
MCHC RBC-EntSCnc
Synonyms
MCHC RBC-EntSCnc
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

MCHC evaluates the hemoglobin concentration packed within each red blood cell. While hemoglobin itself is measured in whole blood samples, MCHC isolates this measurement per cell to identify potential issues like anemia or hemolytic disorders.

Why Might You Need This Test?

Doctors may order MCHC when symptoms like fatigue, pale skin, or unusual bruising suggest red blood cell problems. It can also help diagnose conditions such as thalassemia, sickle cell disease, or iron deficiency.

How Is This Test Performed?

A small blood sample is drawn from a vein, typically in your arm. The blood is then analyzed in a lab to determine the concentration of hemoglobin within each red blood cell.

What Are Common Results and Their Meanings?

Results are not always given as a specific range, as they depend on the lab’s methods and individual health. Abnormally high or low MCHC can signal underlying health concerns that require further evaluation.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MCHC (RBC)

Frequently asked questions

What does a low MCHC mean?
A low MCHC may indicate conditions like iron deficiency anemia, thalassemia, or certain types of hemolytic anemia. Your doctor will review your symptoms, other test results, and medical history to determine the cause and next steps.
What does a high MCHC mean?
A high MCHC can sometimes suggest conditions such as dehydration, spherocytosis, or certain metabolic disorders. Further testing and evaluation by your healthcare provider are needed to understand the underlying reason.
Can lifestyle changes affect MCHC results?
Yes, factors like diet (especially iron intake), hydration status, and certain medications can influence red blood cell health and hemoglobin concentration. Your doctor may recommend lifestyle adjustments or additional tests if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy