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Metanephrines in Urine (Free, Total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of certain chemicals called metanephrines in your urine. These chemicals are byproducts of adrenaline and norepinephrine, hormones that help your body respond to stress.

Quick summary

["Assists doctors in diagnosing conditions linked to abnormal hormone production in the adrenal glands or nerves."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108474-8
Short code
m-CPP Msmt Ur
Synonyms
m-CPP Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like severe headaches, rapid heartbeat, sweating, or unexplained weight loss. It could also be used to check for conditions such as pheochromocytoma (a rare tumor affecting hormone production) or other adrenal or nerve-related disorders.

What to Expect Before the Test

No special preparation is needed. You’ll collect a 24-hour urine sample, starting from one morning and ending the next morning. Drink plenty of water to help your urine flow freely.

What Happens During the Test

Your urine sample will be sent to a lab for analysis. The lab will measure the levels of metanephrines, which are broken down from adrenaline and norepinephrine. This helps determine if there’s an abnormal buildup of these hormones in your body.

What the Results Mean

High levels of metanephrines in urine may suggest conditions like pheochromocytoma or other hormonal imbalances. Low or normal levels do not indicate these conditions but may require further evaluation if symptoms persist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Metanephrines

Frequently asked questions

What causes abnormal urine metanephrines?
Abnormally high levels of metanephrines in urine are most commonly linked to tumors (pheochromocytoma or paraganglioma) affecting the adrenal glands or other parts of the nervous system. Other rare causes may include certain genetic syndromes or excessive stress-related hormone release.
Can diet or medications affect this test?
Yes, certain foods, supplements, or medications (like caffeine, decongestants, or some antidepressants) can influence metanephrine levels. Your doctor may advise avoiding these for a few days before testing to get more accurate results.
How long does it take to get results?
Results typically take 1–2 weeks after your sample is submitted to the lab. Your doctor will discuss the findings with you during a follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy