Creatinine Clearance (Calculated from Serum Creatinine and Estimated Glomerular Filtration Rate)

What Is Creatinine Clearance Used For?

Creatinine clearance is primarily used to evaluate kidney function and diagnose conditions like chronic kidney disease (CKD). It can also help monitor kidney health before and after treatments, such as certain medications or surgeries, or in cases where kidney function may be affected by illness or injury.

How Is This Test Done?

To calculate creatinine clearance, your healthcare provider will typically take a blood sample (serum) and may also ask for a 24-hour urine collection. The test measures creatinine levels in your blood and urine to estimate how much creatinine your kidneys filter out over time.

Why Might You Need This Test?

You may need a creatinine clearance test if you have symptoms of kidney problems (such as swelling, fatigue, or frequent urination), if you have a condition that could affect kidney function (like diabetes or high blood pressure), or if you’re undergoing treatment that could impact kidney health.

What Are the Possible Results?

Results are interpreted as a clearance rate, typically reported in milliliters per minute (mL/min). Lower clearance values may indicate reduced kidney function, while higher values suggest better filtration. Your doctor will compare your result to your age, sex, and overall health to determine if it’s within a normal range.