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Mass concentration of a substance in cerebrospinal fluid (CSF) using immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein content in your cerebrospinal fluid, which helps assess conditions affecting the brain and spinal cord.

Quick summary

["Measuring CSF protein levels can help diagnose or monitor neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26742-7
Short code
MDA Mlk-mCnc
Synonyms
MDA Mlk-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to investigate symptoms like headaches, neurological deficits, or signs of inflammation in the central nervous system. It can also help diagnose conditions such as meningitis, multiple sclerosis, or other spinal cord disorders.

What Does the Test Involve?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed to determine the protein concentration.

Sample Collection and Preparation

The fluid is typically sent to a lab for immunoassay testing, which detects and quantifies proteins in the sample using specific antibodies. This method is sensitive and accurate for measuring protein levels in CSF.

What Are Common Conditions Monitored?

Elevated protein levels in CSF may indicate conditions such as infections (e.g., bacterial or viral meningitis), inflammatory diseases (e.g., multiple sclerosis), or other neurological disorders affecting protein leakage into the CSF.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Mass Concentration (Immunoassay)

Frequently asked questions

What does a high or low protein level in CSF mean?
A high protein level may suggest inflammation, infection, or other neurological issues, while low levels are less commonly significant but could indicate certain congenital or rare conditions. Results should always be interpreted by a healthcare provider in the context of your symptoms and medical history.
How long does it take to get results from this test?
Results are typically available within a few days, depending on lab processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
Is there anything I should do to prepare for this test?
No special preparation is needed for this test. You may be asked to empty your bladder before the procedure, but otherwise, you can proceed as usual. Follow your healthcare provider’s specific instructions for the day of the lumbar puncture.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy