Serum or Plasma Albumin to Globulin Ratio (A/G Ratio)

What Is the Albumin/Globulin Ratio Testing For?

Your A/G ratio can indicate whether your body is producing enough albumin (a protein that helps maintain fluid balance) or if there’s an excess of globulins (proteins involved in immune function and transport). High ratios may suggest liver disease or chronic inflammation, while low ratios could point to malnutrition or kidney problems. This test is often used alongside other blood tests to diagnose conditions like cirrhosis, chronic liver disease, or protein-losing syndromes.

How Is This Test Performed?

A small blood sample is drawn from your arm, typically in a clinic or lab. The blood is processed to separate serum or plasma, where albumin and globulin levels are measured. The ratio is then calculated by comparing the concentrations of these proteins.

Why Might You Need This Test?

Your healthcare provider may order an A/G ratio test if you have symptoms like unexplained weight loss, swelling, fatigue, or signs of liver disease (e.g., jaundice). It may also be part of routine checks for chronic conditions like kidney disease, autoimmune disorders, or malnutrition.

What Do Results Mean?

Results are not given as a single numeric range since they depend on your specific protein levels. A higher ratio may suggest liver disease or inflammation, while a lower ratio could indicate malnutrition or protein loss. Your doctor will interpret results in the context of your overall health and symptoms.