Skip to content

Medium/High-Density Lipoprotein Cholesterol, Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures cholesterol carried by medium- and high-density lipoprotein particles in blood and may be used to help assess cardiovascular risk.

Quick summary

["The result is interpreted with other cholesterol measurements because it does not stand alone."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105508-6
Short code
Med high bld chol
Synonyms
Med high bld chol
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures cholesterol associated with medium- and high-density lipoproteins, which are particles that transport cholesterol through the bloodstream. It is generally considered alongside total, low-density, and high-density cholesterol and triglycerides.

Why might I need this test?

A clinician may order this test as part of a lipid assessment to help estimate the risk of heart disease and stroke. It may also be used to monitor treatment intended to improve cholesterol levels.

How is the test performed?

A blood sample is collected and analyzed in a laboratory. Depending on the laboratory method, the cholesterol content of the lipoprotein fractions may be measured directly or calculated from other lipid results.

How do I prepare for the test?

Fasting is not required for every cholesterol test, although fasting may be requested when triglycerides or a complete lipid profile are being assessed. Follow the laboratory's instructions and tell your clinician if you have recently changed medications, diet, or exercise habits.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Medium/High-Density Lipoprotein Cholesterol

Frequently asked questions

Does a high result mean I have high cholesterol?
Not necessarily. This result covers specific lipoprotein fractions and must be interpreted with total and low-density lipoprotein cholesterol, triglycerides, and your overall cardiovascular risk.
Do I need to fast before this test?
It depends on the laboratory's instructions and the other tests ordered with it. Ask whether an overnight fast is required, and avoid a heavy meal immediately beforehand if fasting is requested.
How often should this test be repeated?
The interval depends on your cardiovascular risk, current lipid levels, medications, and any treatment plan. Your clinician can recommend when repeat testing is appropriate.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy