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Serum or plasma mass concentration of erythropoietin (EPO)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of erythropoietin, a hormone produced by your kidneys that helps your body make red blood cells.

Quick summary

["EPO helps regulate blood production and may be checked if you have anemia or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46255-6
Short code
MEK SerPl-mCnc
Synonyms
MEK SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to evaluate kidney function, diagnose or monitor conditions like anemia, polycythemia (too many red blood cells), or certain cancers. It can also help assess responses to treatments like erythropoiesis-stimulating agents.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm, or if testing urine, you’ll collect a sample in a container. If testing plasma, your blood will be processed immediately.

What the Results Mean

Results are interpreted based on your health status and symptoms. Abnormal levels may indicate kidney problems, blood disorders, or other conditions. Your doctor will discuss findings with you.

Common Conditions Monitored

EPO levels are often checked in patients with chronic kidney disease, those receiving dialysis, or those with conditions like myeloproliferative disorders or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: EPO plays a critical role in maintaining red blood cell production. Low levels may signal kidney dysfunction or anemia, while elevated levels could suggest overproduction (e.g., due to tumors or certain medications).

Short name

EPO level

Frequently asked questions

What causes abnormal EPO levels?
Abnormal EPO levels can result from kidney disease, tumors (such as renal cell carcinoma), or medications that stimulate red blood cell production. Rarely, genetic conditions may also affect EPO levels.
How is EPO tested?
EPO is measured using a blood sample drawn from a vein. The test is typically done on serum or plasma and analyzed via immunoassay or similar methods to detect and quantify the hormone.
Can EPO levels change with diet or exercise?
Dietary factors or exercise alone typically do not significantly alter EPO levels. However, certain medications (e.g., erythropoiesis-stimulating agents) or chronic conditions (e.g., anemia) may influence results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy