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Serum or plasma substance concentration for methylmalonic acid

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid in your blood, which can help diagnose or monitor conditions affecting how your body breaks down certain foods.

Quick summary

["Methylmalonic acid levels may indicate metabolic disorders or vitamin deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50880-4
Short code
MEK SerPl-sCnc
Synonyms
MEK SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, muscle weakness, or unexplained weight loss, or if you have a family history of metabolic disorders. It may also be used to check for conditions like vitamin B12 deficiency or mitochondrial disorders.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed by your provider. Bring any medications you’re currently taking, as some may affect results.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The blood is then sent to a lab for analysis using a specialized method to measure methylmalonic acid concentration.

What the Results Mean

Results are compared to a reference range specific to your lab. Elevated levels may suggest metabolic disorders, while very low levels could indicate vitamin deficiencies or other underlying issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High methylmalonic acid levels often point to inherited metabolic disorders (e.g., methylmalonic aciduria) or vitamin B12 deficiency. Low levels may indicate vitamin B12 or folate deficiency, though further testing is needed to confirm.

Short name

Methylmalonic Acid (Serum/Plasma)

Frequently asked questions

What causes elevated methylmalonic acid levels?
Elevated levels can result from genetic disorders that disrupt fat metabolism, vitamin deficiencies (such as B12 or folate), or certain kidney or liver conditions. Your provider may also check for signs of mitochondrial dysfunction.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your provider will discuss the findings with you during a follow-up visit.
Can I take anything before the test?
Follow your provider’s instructions, but generally, no special diet or fasting is required unless specified. Avoid smoking or consuming alcohol for 24 hours before testing, as these may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy