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Genetic Mutation Detection for Menin (MEN1 Gene) via Whole Blood DNA

Published: August 9, 2026Updated: August 16, 2026

This test checks for mutations in the MEN1 gene, which can be linked to multiple endocrine neoplasia type 1 (MEN1), a rare condition affecting hormone-producing glands. It uses DNA extracted from your blood.

Quick summary

["This test helps assess genetic risk for MEN1-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35288-0
Short code
MEN1 gene Mut Anl Bld/T
Synonyms
MEN1 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test analyzes the MEN1 gene for specific mutations that may be inherited or acquired. These mutations can increase the risk of developing tumors in certain hormone-producing organs, such as the pituitary, adrenal glands, or pancreas.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of MEN1, symptoms of related conditions, or if you’re at higher genetic risk. It’s also used in screening or diagnostic workups for suspected MEN1.

Sample Collection and Process

A blood sample is drawn, typically from a vein in your arm. The DNA is extracted from your white blood cells and tested for known MEN1 gene mutations using advanced laboratory techniques.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications or health conditions that could affect results. Avoid fasting unless instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate a mutation in the MEN1 gene, which may require further evaluation or monitoring. Negative results suggest no detected mutation in this test, but genetic counseling is still recommended for risk assessment and family planning.

Short name

Menin Gene Mutation Test (blood)

Frequently asked questions

What does a positive result mean?
A positive result means the test found a mutation in the MEN1 gene. This may increase your risk of developing tumors in hormone-producing glands, and your doctor will discuss next steps, such as regular monitoring or genetic counseling.
What if my test is negative?
A negative result means no detectable mutation in this test sample. However, some mutations may not be detected by this method, so genetic counseling is still important to discuss your risk and family history.
Can this test detect all possible MEN1 gene mutations?
This test checks for specific mutations commonly associated with MEN1. Some rare mutations may not be detected, so additional genetic testing or family screening may be recommended.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy