Vitamin K-dependent clotting factor activity (serum/plasma mass concentration)
This test measures the activity level of clotting factors influenced by vitamin K, which helps assess how well your blood can clot normally.
["Helps diagnose bleeding disorders or vitamin K deficiencies that may affect blood clotting."]
Key facts at a glance
- LOINC
- 3129-4
- Short code
- Menadione SerPl-mCnc
- Synonyms
- Menadione SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
This test evaluates the functional activity of vitamin K-dependent clotting factors (such as factors II, VII, IX, and X) in your blood. It does not measure vitamin K levels directly but assesses how well these factors work to prevent excessive bleeding.
Why It’s Ordered
Your healthcare provider may order this test if you have symptoms of bleeding disorders (like excessive bruising or nosebleeds), if you’ve been given vitamin K supplements, or if you’re taking medications that affect blood clotting.
Common Conditions Monitored
This test can help diagnose or monitor conditions like vitamin K deficiency, liver disease (which affects clotting factors), or bleeding disorders such as hemophilia or von Willebrand disease.
Sample Collection & Preparation
A blood sample is drawn from a vein, usually in your arm. The sample is collected in a tube that prevents blood clotting (anticoagulant added) and sent to the lab for testing. Results are typically available within 24–48 hours.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Vitamin K Factor Activity
Frequently asked questions
Low levels of vitamin K-dependent clotting factors may indicate bleeding risks, while elevated levels could suggest liver disease or other metabolic issues. This test helps guide treatment decisions, such as vitamin K administration or medication adjustments.
A low result may suggest vitamin K deficiency, liver disease, or certain medications that interfere with blood clotting. Your doctor may recommend vitamin K supplements or further testing.
A high result could indicate liver problems or overproduction of certain clotting factors. This would need evaluation by your healthcare provider to determine the cause.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy