Methadone (Body-Mass-Adjusted) and Creatinine, Urine — Mass Concentration
A urine test measuring methadone and creatinine. Methadone may be adjusted for body mass, while creatinine helps account for differences in urine concentration.
["This test can help assess recent methadone exposure, treatment monitoring, and possible drug accumulation."]
Key facts at a glance
- LOINC
- 78770-5
- Short code
- Methadone adj bodymass+crea Ur-mCnc
- Synonyms
- Methadone adj bodymass+crea Ur-mCnc
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amount of methadone in a urine sample. It may also measure urinary creatinine and adjust the methadone result for body mass, which can help make results more comparable between people.
Why might I need this test?
A clinician may order this test to monitor methadone treatment, check adherence, assess possible toxicity, or evaluate an unexpected result. It may also be used when there is concern about drug interactions or excessive sedation.
How is the test performed?
You provide a urine sample, which is analyzed in a laboratory to determine the methadone and creatinine concentrations. If the report includes a body-mass adjustment or creatinine comparison, your clinician will interpret it along with your dose, timing, and other findings.
How do I prepare for the test?
Fasting is usually not required, but collection time and instructions from the laboratory are important because methadone levels can change throughout the day. Take methadone and other medicines as prescribed unless your clinician tells you otherwise, and tell the clinician about medications or supplements you use.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A higher methadone concentration may reflect recent dosing, a high dose, slow metabolism, drug interactions, or medication accumulation. A lower result does not always mean that methadone was not taken because timing, urine concentration, and individual metabolism can affect the result. Creatinine and body-mass adjustments can make the result more useful, but the clinician must interpret it with the clinical situation.
Short name
Urine Methadone and Creatinine
Frequently asked questions
What does a body-mass-adjusted methadone result mean?
Why is creatinine measured with urine methadone?
Does a high urine methadone level always mean an overdose?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy