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Methamphetamine/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures methamphetamine relative to creatinine, which helps account for differences in urine concentration.

Quick summary

["This test checks whether methamphetamine is present in the urine and reports its amount relative to urine concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58358-3
Short code
Methamphet/Creat Ur
Synonyms
Methamphet/Creat Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures methamphetamine and creatinine in a urine sample. The results may be expressed as a methamphetamine-to-creatinine ratio, which helps account for how concentrated or dilute the urine is.

Why might I need this test?

It may be used in workplace, school, legal, or other drug-screening programs. It may also be ordered to evaluate suspected methamphetamine exposure or monitor treatment for stimulant use.

How is the test performed?

A urine specimen is collected and tested in the laboratory for methamphetamine and creatinine. The laboratory then provides the result, often as a ratio or according to the ordering laboratory's reporting method.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory or testing site. Do not intentionally drink large amounts of water, and tell the collector about any medications or supplements you have recently taken.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A detectable methamphetamine result may indicate recent exposure to methamphetamine or another stimulant that can cause a similar result. The clinical meaning depends on the amount, urine concentration, timing, medication use, and the reason for testing, so the result should be interpreted by a qualified healthcare professional.

Short name

Urine Methamphetamine Ratio

Frequently asked questions

Does this test distinguish methamphetamine from other amphetamines?
Not always. Some substances can produce a similar result, so laboratory confirmation or additional testing may be needed when the finding has important consequences.
Why is creatinine included in the test?
Creatinine helps show how concentrated the urine is. Reporting methamphetamine relative to creatinine makes it easier to compare results from samples with different levels of dilution.
Can medications affect the result?
Yes. Certain medications, including some prescription and over-the-counter products, can cause amphetamine-like results. Inform the healthcare professional ordering or interpreting the test about relevant medication use.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy