Methionine S-Adenosyltransferase (SAT) Activity in Serum/Plasma
This test measures the activity level of methionine S-Adenosyltransferase, an enzyme involved in the production of S-adenosylmethionine, a key molecule for methylation reactions in the body.
["Understanding your SAT activity may help assess metabolic health and potential methylation disorders."]
Key facts at a glance
- LOINC
- 2615-3
- Short code
- MetHgb MFr BldA
- Synonyms
- MetHgb MFr BldA
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Methionine S-Adenosyltransferase (SAT) is an enzyme that plays a critical role in converting methionine into S-adenosylmethionine (SAM), a compound essential for various biochemical processes, including DNA synthesis, neurotransmitter production, and detoxification. This test evaluates how efficiently your body performs these methylation reactions.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms or conditions linked to methylation disorders, such as chronic fatigue, neurological issues, or certain metabolic syndromes. It may also be part of a broader evaluation for genetic or environmental factors affecting methylation pathways.
How Is the Test Performed?
A blood sample is drawn, typically from a vein in your arm. The sample is processed to measure the enzyme’s activity level in your serum or plasma. The test may be performed using an enzymatic method to detect changes in substrate conversion over time.
What Are Possible Results?
Results are presented as enzyme activity units (often normalized to a standard reference), but specific numeric ranges are not universally defined for this test. Your results will be interpreted in relation to your clinical symptoms and overall health.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal SAT activity may indicate underlying issues with methylation, such as deficiencies in SAM production, which can affect how your body processes nutrients, detoxifies toxins, and maintains brain function. Low activity might suggest genetic mutations or conditions like homocystinuria, while elevated levels could point to metabolic imbalances or other systemic disorders. Always discuss results with your healthcare provider for personalized interpretation.
Short name
SAT Activity
Frequently asked questions
What causes low or high SAT activity?
How long does it take to get results?
Can diet or supplements affect SAT activity?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy