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Methylmalonic Acid (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid, a breakdown product of certain amino acids in your body. High levels may signal conditions affecting how your body processes nutrients or energy.

Quick summary

["Methylmalonic acid levels help diagnose metabolic disorders and vitamin deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2616-1
Short code
MetHgb MFr BldC
Synonyms
MetHgb MFr BldC
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85018
SNOMED
900000000000003004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, weight loss, or neurological issues. It’s also used to check for genetic metabolic disorders, vitamin deficiencies (such as B12 or folate), or kidney problems that can affect how your body processes nutrients.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed. Bring any medications you’re currently taking, as they may affect results.

How the Test Works

A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s analyzed to measure methylmalonic acid levels using a specialized chemical test.

What the Results Mean

Results are compared to a reference range, but exact values can vary by lab. High levels may indicate metabolic disorders, vitamin deficiencies, or kidney issues. Low levels are less common but can occur in rare genetic conditions.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Serum/Plasma

Frequently asked questions

What causes elevated methylmalonic acid levels?
Elevated levels can result from vitamin B12 or folate deficiency, certain genetic metabolic disorders, or conditions affecting how your kidneys filter waste. Lifestyle factors like poor nutrition or malabsorption syndromes may also play a role.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss them with you during your follow-up visit.
Can diet affect this test?
Yes, certain foods high in B12 (like meat, eggs, or fortified foods) or folate (leafy greens, beans) may influence results. Follow your provider’s instructions regarding diet before testing to avoid interference.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy