Methylmalonic Acid in Serum or Plasma (Mass Concentration)
This test measures the level of methylmalonic acid (MMA) in your blood, which helps diagnose and monitor certain metabolic conditions.
["MMA levels can indicate vitamin B12 or folate deficiencies or genetic metabolic disorders."]
Key facts at a glance
- LOINC
- 41607-3
- Short code
- MetHgb MFr BldMV
- Synonyms
- MetHgb MFr BldMV
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have symptoms like fatigue, weakness, nerve damage, or unexplained anemia, especially if you have a history of vitamin deficiencies or genetic disorders. It may also be used to check for conditions like methylmalonic aciduria, a rare inherited metabolic disorder.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if your doctor specifies it. Bring any medications or supplements you’re taking to your appointment.
What the Test Involves
A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood sample is then sent to a lab for analysis.
What the Results Mean
High MMA levels may suggest vitamin B12 or folate deficiency, certain genetic disorders, or kidney problems. Low levels are less common but could indicate rare metabolic issues. Your doctor will interpret results in the context of your overall health and symptoms.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated MMA is a key marker for methylmalonic aciduria, a group of inherited disorders affecting how your body breaks down certain fats and amino acids. It can also signal vitamin B12 deficiency, which can cause nerve damage, anemia, or cognitive issues. Regular monitoring helps manage these conditions early.
Short name
MMA (Serum/Plasma)
Frequently asked questions
What causes MMA levels to be high?
How long does it take to get results?
Can diet affect MMA test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy