Methylmalonic Acid in Serum or Plasma (Mass Concentration)
This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a breakdown product of certain amino acids and fatty acids, and elevated levels may signal metabolic issues.
["Elevated MMA can indicate genetic disorders or deficiencies affecting vitamin B12 or folate metabolism."]
Key facts at a glance
- LOINC
- 2617-9
- Short code
- MetHgb MFr BldV
- Synonyms
- MetHgb MFr BldV
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why Might This Test Be Ordered?
Your doctor may request this test if you have symptoms like fatigue, weakness, neurological problems, or if you have a family history of metabolic disorders. It’s also used to monitor conditions like vitamin B12 deficiency or inherited disorders like methylmalonic aciduria.
What Does a Result Mean?
MMA levels can rise in conditions where your body struggles to break down certain substances properly. High levels may suggest genetic disorders, vitamin deficiencies, or kidney problems that affect how MMA is processed.
Sample Collection and Preparation
A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis. If you’re taking vitamin B12 or folate supplements, your doctor may advise stopping them before testing to avoid interference.
Common Conditions Monitored
This test helps diagnose or manage conditions like methylmalonic aciduria, cobalamin (vitamin B12) deficiency, or other inherited metabolic disorders. It’s also used in research or follow-up for patients with unexplained metabolic abnormalities.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
MMA (Serum/Plasma)
Frequently asked questions
What Are My Next Steps If My Results Are Abnormal?
How Often Should I Have This Test?
Can I Take Any Supplements Before the Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy