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Methylmalonic Acid (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a breakdown product of certain amino acids and can indicate metabolic issues.

Quick summary

["High MMA levels may signal vitamin B12 or folate deficiencies or other metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73280-0
Short code
Methyldopa ind plt IgM SerPl Ql FC
Synonyms
Methyldopa ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, weakness, or neurological problems, or if you have conditions like vitamin B12 deficiency, kidney disease, or certain genetic disorders. It can also help monitor treatment for metabolic disorders.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab for analysis using a specialized method to measure MMA levels.

What Are Normal Results?

Normal results vary by lab and method, but they provide a baseline for comparison. Abnormal results may require further testing or medical evaluation.

What If My Results Are Abnormal?

If your MMA levels are high, your doctor may recommend additional tests, such as checking vitamin B12 and folate levels, or other metabolic studies to identify the underlying cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated MMA levels often point to conditions like cobalamin (vitamin B12) deficiency, methylmalonic aciduria (a genetic disorder), or other metabolic disorders. Low levels may suggest folate deficiency or other rare metabolic issues.

Short name

MMA

Frequently asked questions

What causes elevated MMA levels?
Elevated MMA levels can be caused by vitamin B12 or folate deficiencies, certain genetic disorders, kidney disease, or metabolic disorders. Lifestyle factors, such as poor diet, may also play a role.
How is MMA tested?
MMA is measured using advanced laboratory techniques, such as high-performance liquid chromatography (HPLC) or mass spectrometry. These methods detect and quantify the substance in your blood sample.
Can diet affect MMA levels?
Yes, diet can influence MMA levels. A diet low in vitamin B12 or folate may contribute to elevated MMA. Your doctor may recommend dietary changes or supplements if deficiencies are suspected.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy