Skip to content

Metonitazene and Creatinine, Urine — Confirmatory Method

Published: August 9, 2026Updated: August 16, 2026

Confirmatory urine testing for metonitazene, a potent synthetic opioid, often includes urine creatinine to help account for urine concentration.

Quick summary

["A confirmed positive result indicates that metonitazene was detected in the urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101167-5
Short code
Metonitazene/Creat Ur Cfm
Synonyms
Metonitazene/Creat Ur Cfm
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test detects metonitazene, a synthetic opioid also known as a nitazene, in urine. It is generally used to confirm a result from an initial drug screen.

Why might I need this test?

A clinician may order this test after a positive screening result, concern about possible opioid exposure, or as part of an investigation related to an overdose or suspected drug use.

How is the test performed?

A urine sample is collected and analyzed using a laboratory confirmatory method. Urine creatinine may also be measured to show how concentrated or diluted the specimen is.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory or clinician. Urine is usually collected in a sterile cup, and fasting is generally not required; timing and other preparation depend on the reason for testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A confirmed metonitazene result indicates that the substance was detected in the urine, but it does not by itself determine when it was used, how much was taken, or the degree of impairment. Detection may reflect intentional use, accidental exposure, or exposure to contaminated products.

Urine creatinine helps assess the concentration of the urine specimen, which can vary with fluid intake. Creatinine is not a measure of metonitazene toxicity, and its level should not be interpreted that way.

Short name

Urine metonitazene confirmation

Frequently asked questions

What does a positive metonitazene urine test mean?
It means metonitazene was detected in the urine. The result does not alone establish the dose, timing, or severity of exposure.
Is this the same as a routine opioid urine screen?
Not necessarily. Many routine opioid screens do not include metonitazene, so a separate confirmatory test may be needed.
Why is urine creatinine included?
Urine creatinine helps show whether the sample is concentrated or diluted. It does not indicate whether someone experienced an overdose.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy