Mevalonate-to-Creatinine Ratio, Urine
A urine test that measures mevalonate relative to creatinine, helping account for differences in urine concentration.
["This ratio can help evaluate suspected mevalonate metabolism disorders, particularly mevalonate kinase deficiency."]
Key facts at a glance
- LOINC
- 13778-6
- Short code
- Mevalonate/Creat Ur
- Synonyms
- Mevalonate/Creat Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures mevalonate, a substance produced during cholesterol synthesis, in urine. The result is compared with the amount of creatinine in the same urine sample, which helps account for how concentrated or dilute the urine is.
Why might I need this test?
The test may be used when a clinician is evaluating a suspected disorder of mevalonate metabolism, especially mevalonate kinase deficiency. It is usually considered alongside symptoms, medical history, genetic testing, and other laboratory studies.
How is the test performed?
A urine specimen is collected and analyzed in a laboratory. Mevalonate and creatinine are measured, and their relationship is reported as a ratio.
How do I prepare for the test?
Follow the collection instructions provided by your healthcare professional. The specimen may be a single urine sample or a timed collection, and fasting is generally not required unless your clinician specifically requests it.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated mevalonate-to-creatinine ratio may indicate increased mevalonate production and can support evaluation for mevalonate kinase deficiency or another related metabolic disorder. Results should be interpreted with symptoms and other tests because mevalonate levels can be affected by age, diet, and other factors.
Short name
Urinary Mevalonate-to-Creatinine Ratio
Frequently asked questions
Why is creatinine included in the result?
Do I need to fast before this test?
Is this the same as a cholesterol test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy