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Serum Anti-Cardiolipin Antibody (IgG) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against cardiolipin, a phospholipid found in cell membranes, which may indicate an autoimmune condition or increased risk of blood clots.

Quick summary

["Helps assess potential autoimmune or thrombotic risks by detecting specific antibodies in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95165-7
Short code
M gallisep Ab/Pos cntrl Ser IA
Synonyms
M gallisep Ab/Pos cntrl Ser IA
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

Cardiolipin antibodies are proteins your immune system produces in response to the cardiolipin molecule, which is naturally present in your cells. Elevated levels may suggest an autoimmune disorder, such as lupus or antiphospholipid syndrome, or other conditions linked to abnormal blood clotting.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms like unexplained blood clots, recurrent miscarriages, or autoimmune conditions. It can also be part of a broader evaluation for unexplained thrombotic events or connective tissue disorders.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The serum portion of your blood is then tested using an immunoassay method to detect the presence of IgG antibodies against cardiolipin.

What Are Common Results and Their Meanings?

Results are typically reported as either positive or negative for elevated antibody levels. Elevated levels may indicate an autoimmune response, but they do not alone diagnose a condition. Your doctor will consider clinical symptoms and other test results for interpretation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Anti-Cardiolipin IgG

Frequently asked questions

What Are Possible Causes of Abnormal Results?
Abnormal results may be linked to autoimmune diseases (e.g., lupus, rheumatoid arthritis), antiphospholipid syndrome, or other inflammatory conditions. Rarely, they may also occur in people without an underlying condition, so further evaluation is needed.
How Do I Prepare for This Test?
No special preparation is needed, but avoid taking blood-thinning medications (e.g., aspirin) 7–10 days before testing unless instructed otherwise by your doctor.
Will This Test Affect My Medications?
No, this test does not directly interact with medications. However, if you’re on blood thinners or have an autoimmune condition, discuss your results with your doctor to adjust treatment plans as needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy