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Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies directed against metabotropic glutamate receptor 1, a protein involved in brain signaling. These antibodies may be detected in conditions affecting the nervous system.

Quick summary

["This test helps evaluate potential autoimmune or inflammatory conditions in the nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110169-0
Short code
mGluR1 IgG Msmt Ser
Synonyms
mGluR1 IgG Msmt Ser
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

Metabotropic glutamate receptors (mGluRs) are proteins found in the brain that help regulate nerve cell communication. mGluR1 is one such receptor. Antibodies against mGluR1 can sometimes form in the body, particularly in certain neurological disorders. This test checks for the presence of these antibodies in your blood.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like seizures, movement disorders, or other neurological issues that could be linked to an autoimmune response targeting brain proteins. It may also be used in research or specialized diagnostic contexts.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion of your blood is then tested using an immunoassay method to detect mGluR1 antibodies. This process identifies whether your immune system has produced antibodies against this specific receptor.

What Are Possible Results?

A positive result means antibodies against mGluR1 were found in your blood. A negative result indicates no detectable antibodies. Interpretation depends on clinical context, such as your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

mGluR1 Antibody

Frequently asked questions

What Does a Positive Result Mean?
A positive result suggests the presence of mGluR1 antibodies in your blood, which may indicate an autoimmune process targeting this receptor. This finding would need further evaluation by a neurologist or specialist to determine if it aligns with a specific condition.
Will This Test Be Done Alongside Other Tests?
Yes, your healthcare provider may use this test alongside other diagnostic tools, such as imaging, electroencephalograms (EEGs), or additional antibody tests, to better understand your symptoms and guide treatment.
Are There Any Risks or Side Effects?
The blood draw itself carries mild risks like bruising or slight discomfort, but there are no known significant side effects from the antibody testing itself. Always discuss potential risks with your provider before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy