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Glutamate Receptor 1 (mGluR1) Antibody, Serum/Plasma (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies against glutamate receptor 1, a protein involved in brain signaling. These antibodies may be linked to certain autoimmune neurological conditions.

Quick summary

["This screening helps identify potential autoimmune responses affecting brain function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94347-2
Short code
mGluR1 IgG Ser Ql IF
Synonyms
mGluR1 IgG Ser Ql IF
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like unexplained headaches, seizures, movement disorders, or other neurological issues that could suggest an autoimmune cause. It may also be used in research or specialized clinical settings to monitor rare conditions.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on blood thinners, let your doctor know before the test.

What the Test Measures

The test detects the presence of antibodies targeting glutamate receptor 1, a protein critical for nerve cell communication. Positive results suggest an immune system response against this protein, which may indicate conditions like anti-NMDA receptor encephalitis or other autoimmune neurological disorders.

What the Results Mean

A positive screening result means antibodies were found. This does not confirm a diagnosis but may prompt further testing or evaluation by a neurologist or specialist. A negative result means no antibodies were detected in this sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

mGluR1 Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of antibodies against glutamate receptor 1, which may suggest an autoimmune process affecting your nervous system. This finding will need further evaluation by a healthcare provider to determine the next steps, such as additional testing or treatment.
Will I need more tests if this result is positive?
Yes, a positive screening result often requires further diagnostic testing, including confirmatory assays or imaging studies, to identify the underlying cause and guide treatment options.
Can lifestyle changes help if this test is positive?
While lifestyle changes alone may not reverse the autoimmune response, they can support overall health. Work with your doctor to develop a treatment plan that may include medications, therapy, or other interventions tailored to your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy