Glutamate Receptor 1 (mGluR1) Antibody, Immunoassay (Serum/Plasma)
This test measures the presence of antibodies against glutamate receptor 1, a protein involved in brain signaling. These antibodies may be linked to certain autoimmune neurological conditions.
["This test helps evaluate potential autoimmune responses affecting brain function."]
Key facts at a glance
- LOINC
- 101878-7
- Short code
- mGluR1 IgG Titr Ser CBA IFA
- Synonyms
- mGluR1 IgG Titr Ser CBA IFA
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 8
- Ref high
- 61
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- cba-ifa
- CPT
- 82977
- SNOMED
- 3110003
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test detects antibodies directed against glutamate receptor 1 (mGluR1), a protein found in the brain. These antibodies can be part of an immune system response that may affect how neurons communicate. While not all positive results indicate a specific condition, they can be useful in diagnosing or monitoring certain neurological autoimmune disorders.
Why Might This Test Be Ordered?
Your healthcare provider may recommend this test if you have symptoms suggestive of autoimmune neurological conditions, such as seizures, movement disorders, or other neurological symptoms. It may also be used in cases where other tests suggest an immune-mediated process affecting brain function.
What Does a Positive Result Mean?
A positive result indicates the presence of mGluR1 antibodies in your blood. This finding may suggest an autoimmune response targeting these receptors, potentially contributing to neurological symptoms. However, further evaluation and correlation with clinical findings are needed to determine the exact cause and appropriate treatment.
What Does a Negative Result Mean?
A negative result means no detectable antibodies against glutamate receptor 1 were found in your sample. This does not rule out other possible causes of your symptoms, and additional testing may still be necessary.
Reference range
Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Autoimmune Neurological Conditions
Short name
mGluR1 Antibody
Frequently asked questions
What symptoms might this test be used to investigate?
Can this test alone diagnose an autoimmune neurological disorder?
How is this test typically performed?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy