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Methylmalonic Acid (MMA) in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid, a breakdown product of certain amino acids in your blood. It helps assess how well your body is producing vitamin B12 or folate, which are important for red blood cell production and nerve function.

Quick summary

["Methylmalonic acid levels can indicate vitamin deficiencies or metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109988-6
Short code
M-IgA Msmt Ser
Synonyms
M-IgA Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, weakness, or neurological issues (such as tingling in hands/feet), or if they suspect a vitamin B12 or folate deficiency. It’s also used to monitor conditions like pernicious anemia, certain genetic metabolic disorders, or kidney disease that may affect vitamin metabolism.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. If you’re taking vitamin B12 or folate supplements, let your doctor know, as they may affect results.

What the Results Mean

Elevated levels may suggest vitamin B12 deficiency, certain genetic disorders (like methylmalonic aciduria), or kidney problems. Lower-than-normal levels could indicate folate deficiency or other metabolic issues. Your doctor will interpret results in the context of your symptoms and overall health.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like vitamin B12 deficiency anemia, pernicious anemia, or inherited metabolic disorders that disrupt amino acid metabolism.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Serum

Frequently asked questions

What causes elevated MMA levels?
Elevated MMA can result from vitamin B12 or folate deficiencies, certain genetic disorders (such as methylmalonic aciduria), or conditions affecting kidney function. Chronic kidney disease may impair vitamin metabolism, leading to elevated MMA.
Can folate supplements affect MMA levels?
Yes, folate supplements can lower MMA levels, so it’s important to inform your doctor about any recent changes in your vitamin intake before testing.
Is MMA testing always done with serum?
Yes, this test is typically performed on serum, though plasma can also be used. The method (often an immunoassay) detects MMA concentration in the bloodstream.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy