Skip to content

Methylmalonic Acid (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid in your blood, which can help diagnose certain metabolic disorders.

Quick summary

["High levels may signal vitamin B12 or folate deficiency or genetic metabolic issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55924-5
Short code
M-IgM Ser Ql IEP
Synonyms
M-IgM Ser Ql IEP
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immunoelectrophoresis
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, weakness, or neurological problems, or if you have a family history of metabolic disorders. It’s also used to monitor conditions like vitamin deficiencies or inherited disorders affecting how your body breaks down certain foods.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the blood draw if your doctor recommends it. Bring a list of medications to your appointment.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but the procedure usually takes less than five minutes. The blood sample will be sent to a lab for analysis.

What Are Possible Results?

Results are compared to a reference range specific to your lab. Elevated levels may indicate underlying health concerns that need further evaluation, such as vitamin deficiencies or genetic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA (Serum/Plasma)

Frequently asked questions

What Does It Mean If My Levels Are High?
High methylmalonic acid levels can suggest vitamin B12 or folate deficiency, or conditions like methylmalonic aciduria, which is a rare inherited disorder. Your doctor will discuss next steps, such as additional tests or treatment options.
What Does It Mean If My Levels Are Low?
Low levels alone are less common but may be associated with certain genetic disorders or rare metabolic conditions. Your doctor will review your results alongside other factors, like symptoms and lab findings, to guide further evaluation.
How Often Should I Get This Test?
Your doctor will determine how often you need this test based on your health status, symptoms, and any underlying conditions. Regular monitoring may be recommended if you have a known metabolic disorder or risk factors.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy