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Mitochondrial Antibody Profile (Screening)

Published: August 9, 2026Updated: August 17, 2026

This test checks for antibodies that may indicate an autoimmune condition targeting your body’s mitochondria, which are essential energy-producing parts of cells.

Quick summary

["This screening helps identify potential autoimmune disorders affecting mitochondrial function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
58458-1
Short code
Mitochondria Ab pattern Ser IF-Imp
Synonyms
Mitochondria Ab pattern Ser IF-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (autoantibodies) that can target mitochondrial proteins. These antibodies may be present in conditions like autoimmune hepatitis, autoimmune pancreatitis, or other rare mitochondrial disorders. The test is typically performed using a blood sample to screen for these markers.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained fatigue, liver issues, or digestive problems that could be linked to mitochondrial dysfunction. It’s also used in diagnosing certain autoimmune diseases or evaluating unexplained organ dysfunction.

Sample Collection and Process

A small blood sample is drawn from your arm. The sample is then analyzed in a lab to detect the presence of mitochondrial antibodies. Results are usually reported as positive or negative for the specific antibodies tested.

What the Results Mean

A positive result means your blood contains antibodies against mitochondria, which may suggest an autoimmune condition. A negative result means no detectable antibodies were found in this test, but further evaluation may still be needed if symptoms persist.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of mitochondrial antibodies, which may signal an autoimmune response targeting your mitochondria. This could point to conditions like autoimmune hepatitis or other mitochondrial-related disorders, but further testing may be needed to confirm the diagnosis and determine the best treatment plan.
Can this test be used to diagnose all mitochondrial diseases?
This test is primarily a screening tool. While it can help identify conditions linked to mitochondrial antibodies, it may not detect all mitochondrial diseases. Additional tests, clinical evaluation, and sometimes genetic testing may be required for a full diagnosis.
How often should I get this test?
The frequency depends on your symptoms, medical history, and healthcare provider’s recommendations. If you have an ongoing condition or symptoms related to mitochondrial dysfunction, your provider may order this test periodically to monitor your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy