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Mitochondrial Antibody Profile (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may indicate an autoimmune condition targeting your mitochondria, which are essential for energy production in your cells.

Quick summary

["This screening helps identify potential autoimmune disorders affecting mitochondrial function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
8077-0
Short code
Mitochondria Ab Ser-aCnc
Synonyms
Mitochondria Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (autoantibodies) that the immune system may mistakenly produce against mitochondrial proteins. These antibodies can be part of conditions like autoimmune hepatitis, autoimmune pancreatitis, or other systemic autoimmune diseases. The test is typically performed on serum or plasma.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like unexplained liver issues, chronic fatigue, muscle weakness, or digestive problems that could be linked to mitochondrial dysfunction. It’s also used in cases where other tests for autoimmune diseases haven’t provided a clear answer.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the blood draw if your doctor recommends it. Bring any medications you’re currently taking, as some may affect results.

What to Expect During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it’s generally quick and not painful. The blood sample is then sent to a lab for analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Screen

Frequently asked questions

Why might I need this test?
This test is often recommended if you have symptoms like persistent fatigue, unexplained liver problems, or digestive issues that don’t have a clear cause. It helps rule out autoimmune conditions affecting mitochondria.
What does a positive result mean?
A positive result means your body detected antibodies against mitochondrial proteins, which may signal an autoimmune response. This doesn’t always mean you have a specific disease, but it can guide further testing or treatment options.
Can I take medications before the test?
Yes, you can take your usual medications, but let your healthcare provider know if you’re on blood thinners or other medications that might affect the test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy