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Mitochondrial Antibody Profile (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may indicate an autoimmune response targeting mitochondria, a key part of your cells. It helps evaluate conditions like autoimmune hepatitis or other liver-related disorders.

Quick summary

["This screening helps identify potential autoimmune liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17285-8
Short code
Mitochondria Ab Ser IF-aCnc
Synonyms
Mitochondria Ab Ser IF-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like unexplained fatigue, jaundice (yellowing of skin/eyes), abdominal pain, or liver enzyme abnormalities. It’s also used in patients with suspected autoimmune liver diseases or connective tissue disorders.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The lab analyzes your serum for specific mitochondrial antibodies using immunoassay methods.

What Are Common Symptoms to Watch For?

Symptoms like persistent fatigue, dark urine, pale stools, or unexplained weight loss could signal underlying issues this test may help detect. Always discuss symptoms with your healthcare provider.

What Does a Positive Result Mean?

A positive result suggests a higher likelihood of autoimmune activity targeting mitochondria, but further testing (like confirmatory assays) and evaluation by a specialist are needed to determine the cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Screen

Frequently asked questions

How often can I expect this test to be repeated?
If your initial result is positive or unclear, your doctor may repeat the screening or order additional tests (like confirmatory mitochondrial antibody assays) based on your symptoms and medical history. Follow-up depends on individual circumstances.
What should I do if I have mild symptoms but no prior diagnosis?
If you have mild symptoms like fatigue or abdominal discomfort, discuss them with your doctor. They may recommend this screening test or other evaluations to rule out autoimmune or liver-related conditions.
Can lifestyle changes help if this test is positive?
While lifestyle changes like a balanced diet, avoiding alcohol, and managing stress can support overall health, they won’t replace medical evaluation. Work closely with your healthcare team to address underlying causes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy