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Mitochondrial Antigen Antibody Panel (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies against mitochondrial proteins, which may help identify conditions like autoimmune hepatitis or other liver disorders linked to mitochondrial dysfunction.

Quick summary

["This screening may help diagnose rare liver or autoimmune diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63281-0
Short code
Mitochondria M2 Ab Fld Ql IA
Synonyms
Mitochondria M2 Ab Fld Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like unexplained fatigue, jaundice (yellowing of skin/eyes), liver pain, or unexplained liver enzyme abnormalities. It’s also used in cases where other tests don’t clearly explain liver issues or autoimmune conditions.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before drawing blood. Bring a list of medications to your appointment, as some can affect results.

What the Test Involves

A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch, but it’s quick and shouldn’t cause significant discomfort. The blood is then sent to a lab for analysis.

What the Results Mean

Positive results suggest the presence of mitochondrial antibodies, which may indicate conditions like autoimmune hepatitis or other mitochondrial-related disorders. Negative results mean no detectable antibodies were found in this test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Mitochondrial Antibody Test

Frequently asked questions

What does elevated or positive mitochondrial antibody levels indicate?
Positive results may signal autoimmune liver diseases, such as primary biliary cholangitis or autoimmune hepatitis, where the immune system mistakenly attacks mitochondria in liver cells. This can lead to chronic liver inflammation and damage. Further testing and evaluation by a specialist may be needed to confirm a diagnosis and guide treatment.
What if my results are negative?
A negative result means no detectable mitochondrial antibodies were found in this test. However, mitochondrial dysfunction can still occur for other reasons, so your doctor may recommend additional tests or monitoring if symptoms persist.
How often should I get this test?
The frequency depends on your symptoms, medical history, and doctor’s recommendations. If you have a known autoimmune or liver condition, your doctor may order this test periodically to monitor your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy